Cholecystokinin-33    

Synonyms:    CCK-33

Description:    Induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Synthesized in both porcine cerebral cortex and duodenal mucosa. The precursor cleaved by enzymes to produce a number of active cholecystokinins. Brain contains CCK-octapeptide (CCK8) and several CCK-desoctapeptides; whereas blood plasma contains intact CCK33, CCK39, and CCK58 as well as CCK8 and the CCK-desoctapeptides. Distribution differences are due to tissue-specific post-translational processing events. Belongs to the gastrin/cholecystokinin family.

Species:    Porcine

Amino acid sequence:    KAPSGRVSMIKNLQSLDPSHR ISDRDY(SO₃H)MGWM DF-amide

Modified amino acids:    Sulfated Tyr-residue, amidated C-terminal Phe.

Molecular mass:    3918.39

Purity:    >98% by HPLC and MS analysis

Solubility:    Buffer.

Storage:    Freezer (-20°C). Following reconstitution, aliquot and freeze (-20°C).

References:    Wang BJ, Cui ZJ. Am J Physiol Regul Integr Comp Physiol. 2006 Oct 19.