Cd₇-Metallothionein-2A

Synonyms:    Cd₇MT-2A; Cd-MT-II.  

Description:    Highly pure metallothionein-2A from rabbit liver [1]. Noncovalent complex with 7 cadmium ions. Identical to one of the metallothioneins in MT-II preparation from Sigma [2].

Species:    Rabbit.

Amino acid sequence:    *MDPNCSCAAA GDSCTCANSC TCKACKCTSC KKSCCSCCPP GCAKCAQGCI CKGASDKCSC CA

Modified amino acids:    All Cys-residues are in the form of  thiolates, which participate in the binding of seven Cd²⁺ ions. * The N-terminal methionine is acetylated.

Molecular mass:    6892.06

Form:    Lyophilized. 

Purity:    Peptide purity >98% by HPLC. Contains 7 cadmium ions per molecule of metallothionein-2A.

Solubility:    Buffer.

Storage:    Freezer (-20° C). Protect from moisture. In solution at neutral pH and in the presence of oxygen metallothionein is sensitive to oxidation and solutions should not be stored.

References:   [1] Hunziker, P. E., Kaur, P., Wan, M. & Kanzig, A. (1995) Primary structures of 7 metallothioneins from rabbit tissue, Biochem. J. 306, 265-270. [2] Andon B, Barbosa J, Sanz-Nebot V. (2006) Electrophoresis 27, 3661-3670.