Metallothionein-3

description

Synonyms:    Growth Inhibitory Factor - GIF; apo-MT-3;

Description:    Zinc binding protein expressed in the mammalian brain, inhibits growth of cultured neurons and is specifically downregulated in Alzheimer's disease. Recombinant apoprotein.

Species:    Human

Amino acid sequence:    MDPETCPCPS GGSCTCADSC KCEGCKCTSC KKSCCSCCPA ECEKCAKDCV CKGGEAAEAEAEKCSCCQ

Modified amino acids:    None

Purity:    >98% by HPLC (see HPLC analysis)

Molecular mass: calculated mass: 6927.1; measured mass: 6927.1

Form:    Lyophilized.

Solubility:    Buffer.

Storage:     Freezer (-20° C). Protect from moisture. In solution at neutral pH and in the presence of oxygen metallothionein is sensitive to oxidation and solutions should not be stored.

References:    [1] Uchida, Y., et al. 1991. Neuron 7, 337; [2] Palmiter, R. et al. 1992. PNAS 89, 6333;  [3] Yu, W.H., et al. 2002. Brain Res. 894, 37.