Myelin Basic Protein

Synonyms:    MBP; 

Description:    Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane.

Species:    Porcine

Amino acid sequence:   

Acetyl-ASQKRPSQRH GSKYLASAST MDHARHGFLP RHRDTGIL DSL GRFFGADRGA PKRGSGKDGH HAARTTHYGS LPQKAQHGRP QDENPVVHFF KNIVTPRTPP PSQGKGRGLS LSRFSWGAEG QKPGFGYGGR APDYKPAHKG LKGAQDAQGT LSKIFKLGGR DSRSGSPMAR R

Modified amino acids:    N-terminallly acetylated; mono- and di-methylated at Arg-107 (red).

Molecular mass:    18641.87 (non-methylated form).

Purity:    >98% by HPLC of the mixture of mono-, di- and non-methylated forms.

Solubility:    Buffer.

Storage:    Freezer (-20°C). Protect from moisture. Following reconstitution, aliquot and freeze (-20°C).

References:   Kira J.-I., Debler G.E., Krutzsch H.C., Martenson R.E. Amino acid sequence of porcine myelin basic protein. J. Neurochem. 44: 134-142 (1985).