Zn₇-Metallothionein-4

Synonyms:    Zn₇MT-4; Zn-MT-II.  

Description:    Noncovalent complex with 7 zinc ions.

Species:    Mouse.

Amino acid sequence:    MDPGECTCMS GGICICGDNC KCTTCSCKTC RKSCCPCCPP GCAKCARGCI CKGGSDKCSC CP

Modified amino acids:    All Cys-residues are in the form of  thiolates, which participate in the binding of seven Zn²⁺ ions.

Molecular mass:    6276.59

Form:    Lyophilized. 

Purity:    Peptide purity >98% by HPLC. Contains 7 Zinc ions per molecule of metallothionein-4.

Solubility:    Buffer.

Storage:    Freezer (-20° C). Protect from moisture. In solution at neutral pH and in the presence of oxygen metallothionein is sensitive to oxidation and solutions should not be stored.

References:   Quaife, C. J., Findley, S. D., Erickson, J. C., Froelick, G. J., Kelly, E. J., Zambrowicz, B. P. & Palmiter, R. D. (1994) Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia, Biochemistry. 33, 7250-7259.